Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain

De Santis S, Cosa-Linan A, Garcia-Hernandez R, Dmytrenko L, Vargova L, Vorisek I, Stopponi S, Bach P, Kirsch P, Kiefer F, Ciccocioppo R, Sykova E, Moratal D, Sommer WH, Canals S.
Science Advances. 2020 June 24; 6(26) eaba0154 DOI: 10.1126/sciadv.aba0154

KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain

Lipinski M, Muñoz-Viana R, Del Blanco B, Marquez-Galera A, Medrano-Relinque J, Caramés JM, Szczepankiewicz AA, Fernandez-Albert J, Navarrón CM, Olivares R, Wilczyński GM,Canals S, Lopez-Atalaya JP, Barco A.
Nat Commun. 2020 May 22;11(1):2588. doi: 10.1038/s41467-020-16246-0.

Multishell diffusion imaging reveals sex-specific trajectories of early white matter degeneration in normal aging

Toschi N, Gisbert RA, Passamonti L, Canals S, De Santis S
Neurobiol Aging. 2020;86:191-200. doi:10.1016/j.neurobiolaging.2019.11.014

Inferring correlations associated to causal interactions in brain signals using autoregressive models

López-Madrona VJ, Matias FS, Mirasso CR, Canals S, Pereda E.
Sci Rep. 2019;9(1):17041. doi:10.1038/s41598-019-53453-2

Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging

De Santis S, Sommer WH, Canals S
ACS Chem Neurosci. Sep 12. doi: 10.1021/acschemneuro.9b00481

Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence

De Santis S, Bach P, Pérez-Cervera L, Cosa-Liñan A, Weil G, Vollstädt-Klein S, Hermann D, Kiefer F, Kirsch P, Ciccocioppo R, Sommer WH, Canals S
JAMA Psychiatry. 2019 Jul 1;76(7):749-758. doi: 10.1001/jamapsychiatry.2019.0318.

Non-invasive MRI windows to neuroinflammation

De Santis S., Canals S.
Neuroscience 2019 Apr 1, 403, 1-150 (Special Issue)

Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone

Bach P, Weil G, Pompili E, Hoffmann S, Hermann D, Vollstädt-Klein S, Mann K, Perez U, Moratal D, Canals S, Dursun S, Greenshaw A, Kirsch P, Kiefer F, Sommer W.
Addict Biol. 2020 Jan;25(1):e12717. doi: 10.1111/adb.12717.

Silent Learning

Rossato JI, Moreno A, Genzel L, Yamasaki M, Takeuchi T, Canals S, Morris RGM.
 2018 Nov 5;28(21):3508-3515.e5. doi: 10.1016/j.cub.2018.09.012.

Mapping Functional Connectivity in the Rodent Brain Using Electric-Stimulation fMRI.

Pérez-Cervera L, Caramés JM, Fernández-Mollá LM, Moreno A, Fernández B, Pérez-Montoyo E, Moratal D, Canals S, Pacheco-Torres J.
 2018;1718:117-134. doi: 10.1007/978-1-4939-7531-0_8.

Finding influential nodes for integration in brain networks using optimal percolation theory

Gino Del Ferraro, Andrea Moreno, Byungjoon Min, Flaviano Morone, Úrsula Pérez-Ramírez, Laura Pérez-Cervera, Lucas C. Parra, Andrei Holodny, Canals S & Hernán A. Makse
 2018 Jun 11;9(1):2274. doi: 10.1038/s41467-018-04718-3

Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study.

Lucia FS, Pacheco-Torres J, González-Granero S, Canals S, Obregón MJ, García-Verdugo JM, Berbel P.
 2018 Apr 27;12:31. doi: 10.3389/fnana.2018.00031

High frequency neurons determine effective connectivity in neuronal networks.

Pariz A, Esfahani ZG, Parsi SS, Valizadeh A, Canals S, Mirasso CR.
2018 Feb 1;166:349-359. doi: 10.1016/j.neuroimage.2017.11.014.

Structural and functional, empirical and modeled connectivity in the cerebral cortex of the rat

Díaz-Parra A, Osborn Z, Canals S, Moratal D, Sporns O.
2017 Oct 1;159:170-184. doi: 10.1016/j.neuroimage.2017.07.046.

Functional MRI of Synaptic plasticity

Pacheco-Torres J, Moreno A, Fernández B, Pérez-Cervera L, Caramés JM, Pérez-Montoyo E, Fernández-Mollá LM, Martínez-Sánchez M, Moratal D and Canals S
In: Handbook of In Vivo Neural Plasticity Techniques (ISBN: 9780128120286): A Systems Neuroscience Approach to the Neural Basis of Memory and Cognition (Elsevier). Editor: Denise Manahan-Vaughan Libro

How Do Interconnected Neuronal Networks Adjust to External Stimulation: Parametric Studies of DBS-FMRI

Moya J, Torres D, Moratal D, Canals S
In: Ibáñez J., González-Vargas J., Azorín J., Akay M., Pons J. (eds) Converging Clinical and Engineering Research on Neurorehabilitation II. Biosystems & Biorobotics, vol 15. Springer, Cham

Frequency-Dependent Gating of Hippocampal-Neocortical Interactions

2016 May;26(5):2105-2114. doi: 10.1093/cercor/bhv033.  

Tuning noninvasive brain stimulation with MRI to cope with intersubject variability

Habich A, Canals S, Klöppel S.
Curr Opin Neurol. Libro Clave: A Volumen: 29(4):453-8

Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens

Hadar R, Vengeliene V, Barroeta Hlusicke E, Canals S, Noori HR, Wieske F, Rummel J, Harnack D, Heinz A, Spanagel R, Winter C
Transl Psychiatry Libro Clave: A Volumen: 21;6(6):e840. doi: 10.1038/tp.2016.100

Brain activation induced by voluntary alcohol and saccharin drinking in rats assessed with manganese-enhanced magnetic resonance imaging

Dudek M, Abo-Ramadan U, Hermann D, Brown M, Canals S, Sommer WH, Hyytiä P
Addict Biol Libro Clave: A Volumen: doi: 10.1111/adb.12179. Fecha: 2014

Adult newborn neurons are involved in learning acquisition and long-term memory formation: The distinct demands on temporal neurogenesis of different cognitive tasks

Suárez-Pereira I, Canals S, Carrión AM
Hippocampus Libro Clave: A Volumen: 25(1) Páginas, inicial: 51 final: 61 Fecha: 2014

Widespread vestibular activation of the rodent cortex

Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW
J. Neurosci. Libro Clave: A Volumen: doi: 10.1523/JNEUROSCI.1869-14.2015.

Neurosurgery planning in rodents using a magnetic resonance imaging assisted framework to target experimentally defined networks

Pallarés V, Moya J, Samper-Belda FJ, Canals S, Moratal D
Comput Methods Programs Biomed Libro Clave: A Volumen: 121(2) Páginas, inicial: 66 final: 76

Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features

Aller MI, Pecoraro V, Paternain AV, Canals S, Lerma J
J. Neurosci. Libro Clave: A Volumen: 35(40) Páginas, inicial: 13619 final: 13628

Brain size regulations by cbp haploinsufficiency evaluated by in-vivo MRI based volumetry

Ateca-Cabarga JC, Cosa A, Pallarés V, López-Atalaya JP, Barco Á, Canals S, Moratal D.
Sci. Rep. Libro Clave: A Volumen: 5 Páginas, inicial: 12256

Phenotyping the central nervous system of the embryonic mouse by Magnetic Resonance Microscopy

Martínez-Martínez, M.A., Pacheco-Torres, J., Borrell, V., Canals S
Neuroimage Libro Clave: A Volumen: 97 Páginas, inicial: 95 final: 106 Fecha: 2014

Functional MRI in mice lacking IP3-dependent calcium signalling in astrocytes

Jego, P., Pacheco-Torres, J., Araque, A., Canals S
J. Cereb. Blood Flow Metab Libro Clave: A Volumen: 34 Páginas, inicial: 1599 final: 603 Fecha: 2014

Avoiding catastrophic failure in correlated networks of networks

Reis S, Hu Y, Babino A, Andrade JA, Canals S, Sigman M, Makse H
Nature Physics Libro Clave: A Volumen: 10(762) doi:10.1038/nphys3081

Functional MRI of long-term potentiation: imaging network plasticity

Alvarez-Salvado E, Pallarés V, Moreno A, Canals S
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130152.

Amelioration of ischemic brain damage by peritoneal dialysis

Godino MD, Romera VG, Sánchez-Tomero JA, Pacheco J, Canals S, Lerma J, Vivancos J, Moro MA, Torres M, Lizasoain I, Sánchez-Prieto J
J Clin Invest Libro Clave: A Volumen: 123 Páginas, inicial: 4359 final: 4363 Fecha: 2013

Neurophysiological, metabolic and cellular compartments that drive neurovascular coupling and neuroimaging signals

Moreno A, Jego P, de la Cruz F, Canals S
Front Neuroenergetics Libro Clave: A Volumen: 5 doi: 10.3389/fnene.2013.00003. Fecha: 2013

Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes

Del Pino I, García-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, Martínez de Lagrán M, Ciceri G, Gabaldón MV, Moratal D, Dierssen M, Canals S, Marín O, Rico B
Neuron Libro Clave: A Volumen: 79 Páginas, inicial: 1152 final: 1168 Fecha: 2013

Unsupervised segmentation of brain regions with similar microstructural properties: application to alcoholism

Cosa A, Canals S, Valles-Lluch A, Moratal D
Conf Proc IEEE Eng Med Biol Soc Libro Clave: A Vol: 2013 Páginas, inicial: 1053 final: 1056 Fecha: 2013

Biocytin-based Contrast Agents for Molecular Imaging: An Approach to developing New In Vivo Neuroanatomical Tracers for MRI

Mishra, A., Dhingra, K., Schüz, A., Engelman, J., Beyerlein, M., Logothetis, N.K., Canals S
Neuroimaging Clave: CL Volumen: ISBN: 978-953-307-413-9 Editorial INTECH Fecha: 2011

Biocytin-derived MRI Contrast Agent for Longitudinal Brain Connectivity Studies

Mishra, A.*, Schüz, A., Engelmann, J., Beyerlein, M., Logothetis, N.K. Canals S
ACS Chem. Neurosci. Libro Clave: A Volumen: 2 Páginas, inicial: 578 final: 587 Fecha: 2011

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement

Lopez-Atalaya, J.P., Ciccarelli, A., Viosca, J., Valor, L.M., Jimenez-Minchan, M., Canals S., Giustetto, M. and Barco, A
EMBO J. Libro Clave: A Volumen: 30 Páginas, inicial: 4287 final: 4298 Fecha: 2011

Behavioral, electrophysiological and histopathological consequences of manganese administration in MEMRI

Eschenko, O., Canals S, Simanova, I. and Logothetis, N.K
Magn. Reson. Imaging Libro Clave: A Volumen: 28 Páginas, inicial: 1165 final: 1174 Fecha: 2010

Mapping of functional brain activity in freely behaving rats during voluntary running using manganese-enhanced MRI: implications for longitudinal studies

Eschenko, O., Canals S., Simanova, I., Beyerlein, M., Murayama, Y. and Logothetis, N.K
Neuroimage Libro Clave: A Volumen: 49 Páginas, inicial: 2544 final: 2555 Fecha: 2010

In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration

Mamedov, I., Canals S., Henig, J., Beyerlein, M., Murayama, Y., Mayer, H.A., Logothetis, N.K. and Angelovski, G
ACS Chem. Neurosci. Libro Clave: A Volumen: 1 Páginas, inicial: 819 final: 818 Fecha: 2010

Functional MRI evidence for LTP-induced neural network reorganization

Canals S, Beyerlein, M., Merkle, H. and Logothetis, N.K.
Current Biology Libro Clave: A Volumen: 19 Páginas, inicial: 398 final: 403 Fecha: 2009

Improved neuronal tract-tracing with stable biocytin-derived neuroimaging agents

Mishra, A., Dhingra, K., Schüz, A., Logothetis, N.K. and Canals S
ACS Chem. Neurosci. Libro Clave: A Volumen: 1 Páginas, inicial: 129 final: 138 Fecha: 2009

Magnetic Resonance Imaging of cortical connectivity in vivo

Canals S, Beyerlein, M., Keller, A.L., Murayama Y., Logothetis, N.K.
Neuroimage Libro Clave: A Volumen: 40 Páginas, inicial: 458 final: 472 Fecha: 2008

Electric stimulation fMRI of the perforant pathway to the rat hippocampus

Canals S, Beyerlein, M., Murayama Y., Logothetis, N.K.
Magn. Reson. Imaging Libro Clave: A Volumen: 26 Páginas, inicial: 978 final: 986 Fecha: 2008

Subcellular Mechanisms of Spreading Depression: From Membrane Channels to the DC Voltage Signal

Herreras, O., Makarova, J., Canals S., and Ibarz, J.M
Recent Advances and New Strategies in Stroke Research Clave: CL Fecha: 2008 Editorial (si libro): Research Signpost Lugar de publicación: Kerala, India

Smart magnetic resonance imaging agents that sense extracellular calcium fluctuations

Angelovski, C., Fouskova, P., Mamedov, I., Canals S., Toth, E., Logothetis, N.K
Chembiochem Libro Clave: A Volumen: 9 Páginas, inicial: 1729 final: 1734 Fecha: 2008

Metabolic challenge to glia activates an adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves

Canals S, Larrosa, B., Pintor, J., Mena, M.A., Herreras, O
J Cereb Blood Flow Metab. Libro Clave: A Volumen: 28 Páginas, inicial: 1835 final: 1844 Fecha: 2008

A steady-state model of spreading depression predicts the importance of an unknown conductance in specific dendritic domains

Makarova, I., Ibarz, JM.,Canals S., Herreras, O.
Biophys. J. Libro Clave: A Volumen: 92 Páginas, inicial: 4216 final: 4232 Fecha: 2007

Synaptically recruited apical currents are required to initiate axonal and apical spikes in hippocampal pyramidal cells: modulation by inhibition

Canals S., López-Aguado, L., Herreras, O.
J. Neurophysiol. Libro Clave: A Volumen: 93 Páginas, inicial: 909 final: 918 Fecha: 2005

Longitudinal depolarization gradients along the somatodendritic axis of CA1 pyramidal cells: a novel feature of spreading depression

Canals S., Makarova, I., Lopez-Aguado, L., Largo, C., Ibarz, JM., Herreras, O
J. Neurophysiol. Libro Clave: A Volumen: 94 Páginas, inicial: 943 final: 951 Fecha: 2005

Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures

de Bernardo, S., Canals S., Casarejos, M.J., Solano, R.M., Menendez, J., Mena, M.A.
J. Neurochem. Libro Clave: A Volumen: 91 Páginas, inicial: 667 final: 682 Fecha: 2004

Nitric oxide and dopamine neurons. Implications for Parkinson’s disease

Nitric oxide and dopamine neurons. Implications for Parkinson’s disease
Curr Med Chem Libro Clave: R Volumen: 5 Páginas, inicial: 193 final: 205 Fecha: 2004

Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase

Canals S, Casarejos, M.J., de Bernardo, S., Rodríguez-Martín, E and Mena, M.A.
J. Biol. Chem. Libro Clave: A Volumen: 278 Páginas, inicial: 21542 final: 21549 Fecha: 2003

Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways

de Bernardo, S., Canals S., Casarejos, M.J., Rodríguez-Martín, E., Mena, M.A.
J. Neurosci. Res. Libro Clave: A Volumen: 73 Páginas, inicial: 818 final: 830 Fecha: 2003

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

Itier, J.M., Ibanez, P., Mena, M.A., Abbas, N., Cohen-Salmon, C., Bohme, G.A., Laville, M., Pratt, J., Corti, O., Pradier, L., Ret, G., Joubert, C., Periquet, M., Araujo, F., Negroni, J., Casarejos, M.J.,Canals S, Solano, R., Serrano, A., Gallego, E., Sanchez, M., Denefle, P., Benavides, J., Tremp, G., Rooney, T.A., Brice, A., Garcia de Yebenes, J.
Hum. Mol. Genet. Libro Clave: A Volumen: 12 Páginas, inicial: 2277 final: 2291 Fecha: 2003

Selective and persistent activation of extracellular signal-regulated protein kinase by nitric oxide in glial cells induces neuronal degeneration in glutathione-depleted midbrain cultures

Canals S, Casarejos, M.J., de Bernardo, S., Solano, R.M., Mena, M.A.
Mol. Cell Neurosci. Libro Clave: A Volumen: 24 Páginas, inicial: 1012 final: 1026 Fecha: 2003

Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for Parkinson’s disease

Canals S, Casarejos, M.J., de Bernardo, S., Rodríguez-Martín, E and Mena, M.A.
J. Neurochem. Libro Clave: A Volumen: 79 Páginas, inicial: 1183 final: 1195 Fecha: 2002

The role of astroglia on the survival of dopamine neurons

Mena, M.A., de Bernardo, S., Casarejos, M.J., Canals S, Rodríguez-Martín, E.
Mol. Neurobiol. Libro Clave: R Volumen: 25 Páginas, inicial: 245 final: 263 Fecha: 2002

Thiolic antioxidants protect from nitric oxide-induced toxicity in fetal midbrain cultures

Rodríguez-Martín, E., Casarejos, M.J., Canals S., de Bernardo, S. and Mena, M.A.
Neuropharmacology. Libro Clave: A Volumen: 43 Páginas, inicial: 877 final: 888 Fecha: 2002

Neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures

Canals S, Casarejos, MJ., Rodriguez-Martin, E., De Bernardo, S., and Mena, MA.
J. Neurochem. Libro Clave: A Volumen: 76 Páginas, inicial: 56 final: 68 Fecha: 2001

L-DOPA and glia-conditioned medium have additive effects on tyrosine hydroxylase expression in human catecholamine-rich neuroblastoma NB69 cells

Rodríguez-Martín, E., Canals S, Casarejos, MJ., de Bernardo, S., Handler, A., and Mena, M.A.
J. Neurochem. Libro Clave: A Volumen: 78 Páginas, inicial: 535 final: 545 Fecha: 2001

The effects of acute treatment with 9-THC on exploratory behaviour and memory in the rat

Hernández-Tristán R., Arévalo C., Canals S, Leret M.L.
J. Physiol. Biochem. Libro Clave: A Volumen: 56 Páginas, inicial: 17 final: 24

Nitric oxide induces differentiation in the NB69 human catecholamine-rich cell line

Rodríguez-Martín, E., Casarejos, M.J., Bazán, E., Canals S., Herranz, A.S. and Mena, M.A.
Neuropharmacology Libro Clave: A Volumen: 39 Páginas, inicial: 2090 final: 2100 Fecha: 2000

Effect of prenatal uterine position on male and female rats sexual behaviour

Hernández-Tristán R., Arévalo C., Canals S
Physiol. Behav. Libro Clave: A Volumen: 67 Páginas, inicial: 401 final: 408